Motif ID: STAT5{A,B}.p2

Z-value: 1.759


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B



Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_39860398 7.104 NM_001012320
NM_018443
 ZNF302

zinc finger protein 302

chr19_-_39859997 6.218


chr19_+_42099073 2.868 NM_198539
 ZNF568
zinc finger protein 568
chr19_-_42098758 2.812 NM_001171979
 ZNF829
zinc finger protein 829
chr1_+_148137778 2.267 NM_016074
 BOLA1
bolA homolog 1 (E. coli)
chr19_+_49180171 2.216 NM_003445
NM_198089
 ZNF155

zinc finger protein 155

chr19_-_62912347 2.112 NM_001085384
 ZNF154
zinc finger protein 154
chr19_+_62972861 1.859 ZNF586
zinc finger protein 586
chr19_+_61798434 1.774 NM_021216
 ZNF71
zinc finger protein 71
chr5_+_145297490 1.581 SH3RF2
SH3 domain containing ring finger 2
chr19_+_62972808 1.557 NM_017652
 ZNF586
zinc finger protein 586
chr19_+_49248003 1.555 NM_013361
 ZNF223
zinc finger protein 223
chr19_+_49198916 1.521 NM_006300
 ZNF230
zinc finger protein 230
chr19_-_42098919 1.499 NM_001037232
 ZNF829
zinc finger protein 829
chr19_-_49552638 1.360 NM_001083335
NM_013380
 ZFP112

zinc finger protein 112 homolog (mouse)

chr4_+_86615275 1.294 NM_001025616
 ARHGAP24
Rho GTPase activating protein 24
chr15_-_81744469 1.249 NM_001717
 BNC1
basonuclin 1
chr19_-_49309102 1.245 LOC100379224
hypothetical LOC100379224
chr19_-_41849558 1.242 NM_153257
 ZNF461
zinc finger protein 461
chr19_-_63643400 1.229 NM_003433
 ZNF132
zinc finger protein 132
chr19_+_42033564 1.150 ZNF345
zinc finger protein 345
chrX_+_105932536 1.138 NM_017752
NM_198881
 TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr19_-_62680703 1.118 NM_001024596
NM_001144068
 ZNF772

zinc finger protein 772

chr19_+_49309350 1.103 NM_013362
 ZNF225
zinc finger protein 225
chr19_+_49268106 0.956 NM_001037813
 ZNF284
zinc finger protein 284
chr20_+_12937616 0.937 NM_018327
 SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr9_+_111582317 0.934 NM_053016
NM_007203
NM_147150
 PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr6_-_32892705 0.893 NM_002120
 HLA-DOB
major histocompatibility complex, class II, DO beta
chr3_-_185025989 0.888 NM_024871
 MAP6D1
MAP6 domain containing 1
chr19_+_42033106 0.886 NM_003419
 ZNF345
zinc finger protein 345
chr19_+_58733144 0.879 NM_001079906
 ZNF331
zinc finger protein 331
chr12_+_11694172 0.853 ETV6
ets variant 6
chr19_-_61596681 0.825 NM_144690
 ZNF582
zinc finger protein 582
chrX_-_48818585 0.817 NM_007213
 PRAF2
PRA1 domain family, member 2
chr19_+_42400908 0.773 ZNF383
zinc finger protein 383
chr5_+_57914658 0.764 NM_138453
 RAB3C
RAB3C, member RAS oncogene family
chr8_-_99375739 0.756 NM_024759
 NIPAL2
NIPA-like domain containing 2
chr19_-_63205948 0.739 ZNF606
zinc finger protein 606
chr14_-_69953433 0.735 NM_018373
 SYNJ2BP
synaptojanin 2 binding protein
chr22_+_48966394 0.730 TRABD
TraB domain containing
chr14_+_23700261 0.703 NM_006084
 IRF9
interferon regulatory factor 9
chr6_-_46728188 0.683 NM_016593
 CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr17_+_36515166 0.682 NM_001146041
 KRTAP4-9
keratin associated protein 4-9
chr19_-_49644470 0.675 NM_014518
 ZNF229
zinc finger protein 229
chr19_-_49097774 0.661 LOC100505715
hypothetical LOC100505715
chr1_-_151788341 0.648 NM_002960
 S100A3
S100 calcium binding protein A3
chr12_+_12857516 0.639 NM_016355
NM_201224
 DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

chr19_+_49337568 0.635 ZNF234
zinc finger protein 234
chr1_-_199704773 0.624 NM_012396
 PHLDA3
pleckstrin homology-like domain, family A, member 3
chr19_+_49290319 0.614 NM_013398
 ZNF224
zinc finger protein 224
chr5_+_178383381 0.613 NM_001136116
 ZNF879
zinc finger protein 879
chr1_-_219977424 0.601 NM_144728
 DUSP10
dual specificity phosphatase 10
chr19_+_58715988 0.586 NM_018555
 ZNF331
zinc finger protein 331
chrX_+_107174855 0.586 NM_001170553
NM_182607
 VSIG1

V-set and immunoglobulin domain containing 1

chr19_-_49131250 0.581 NM_003425
 ZNF45
zinc finger protein 45
chr19_+_49337548 0.580 NM_001144824
NM_006630
 ZNF234

zinc finger protein 234

chr19_-_62782066 0.569 ZNF416
zinc finger protein 416
chr17_+_29606408 0.569 NM_002982
 CCL2
chemokine (C-C motif) ligand 2
chr5_+_14493905 0.565 TRIO
triple functional domain (PTPRF interacting)
chr13_-_32822759 0.564 STARD13
StAR-related lipid transfer (START) domain containing 13
chr19_-_62781883 0.560 NM_017879
 ZNF416
zinc finger protein 416
chr19_+_49455872 0.548 NM_181756
 ZNF233
zinc finger protein 233
chr7_+_47801413 0.547 NM_025031
 PKD1L1
C7orf69
polycystic kidney disease 1 like 1
chromosome 7 open reading frame 69
chr19_+_45168872 0.546 NM_006503
NM_153001
 PSMC4

proteasome (prosome, macropain) 26S subunit, ATPase, 4

chr19_-_49500966 0.533 NM_004234
 ZNF235
zinc finger protein 235
chr9_+_70161634 0.526 NM_021965
 PGM5
phosphoglucomutase 5
chr11_-_82674546 0.516 CCDC90B
coiled-coil domain containing 90B
chr6_+_139136349 0.501 NM_015439
 CCDC28A
coiled-coil domain containing 28A
chr17_-_17435631 0.492 NM_148172
 PEMT
phosphatidylethanolamine N-methyltransferase
chr14_-_67232172 0.475 NM_016026
 RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr3_+_132228383 0.473 NM_001146003
NM_024800
NM_145910
 NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr10_-_98315090 0.470 TM9SF3
transmembrane 9 superfamily member 3
chr15_-_57452345 0.469 MYO1E
myosin IE
chr5_+_178300799 0.462 NM_001178089
NM_001178090
NM_182594
 ZNF454


zinc finger protein 454


chr15_-_57452357 0.455 MYO1E
myosin IE
chr10_-_121345968 0.454 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr9_+_135994734 0.454 NM_052821
 WDR5
WD repeat domain 5
chr14_-_19951417 0.438 NM_007110
 TEP1
telomerase-associated protein 1
chr21_-_35174742 0.434 RUNX1
runt-related transcription factor 1
chr2_-_142605010 0.433 LRP1B
low density lipoprotein receptor-related protein 1B
chr1_+_151897768 0.431 NM_012437
 SNAPIN
SNAP-associated protein
chr15_-_57452361 0.431 NM_004998
 MYO1E
myosin IE
chr16_-_3025542 0.430 NM_001103175
 CCDC64B
coiled-coil domain containing 64B
chr19_-_63150825 0.429 NM_005773
 ZNF256
zinc finger protein 256
chr15_-_72540518 0.427 UBL7
ubiquitin-like 7 (bone marrow stromal cell-derived)
chr17_-_30724732 0.418 NM_001104587
NM_001104588
NM_001104589
NM_001104590
NM_152270
 SLFN11




schlafen family member 11




chr13_-_98202884 0.414 NM_005073
 SLC15A1
solute carrier family 15 (oligopeptide transporter), member 1
chr5_-_178090203 0.413 NM_005649
 ZNF354A
zinc finger protein 354A
chr5_+_150008030 0.407 SYNPO
synaptopodin
chr17_-_18526296 0.407 NM_001145045
 ZNF286B
zinc finger protein 286B
chr19_-_61874934 0.404 ZNF835
zinc finger protein 835
chr3_-_112796855 0.401 NM_024508
 ZBED2
zinc finger, BED-type containing 2
chr15_+_39853982 0.400 MAPKBP1
mitogen-activated protein kinase binding protein 1
chr11_-_100959868 0.395 NM_004621
 TRPC6
transient receptor potential cation channel, subfamily C, member 6
chr14_+_67356248 0.394 NM_002877
NM_133509
NM_133510
 RAD51L1


RAD51-like 1 (S. cerevisiae)


chr2_-_142605739 0.382 NM_018557
 LRP1B
low density lipoprotein receptor-related protein 1B
chr9_-_133944877 0.381 MED27
mediator complex subunit 27
chr3_+_125586241 0.379 KALRN
kalirin, RhoGEF kinase
chr19_+_49361054 0.375 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
 ZNF226




zinc finger protein 226




chr10_-_33663305 0.368 NRP1
neuropilin 1
chr15_+_72540655 0.361 LOC440288
similar to FLJ16518 protein
chr19_+_9112052 0.356 NM_001190791
NM_020933
 ZNF317

zinc finger protein 317

chr3_+_197951203 0.352 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr19_-_49696322 0.348 NM_013256
 ZNF180
zinc finger protein 180
chr7_-_87774130 0.340 NM_024636
 STEAP4
STEAP family member 4
chr8_+_8597075 0.335 NM_194284
 CLDN23
claudin 23
chr1_+_161305558 0.334 NM_001113381
 RGS4
regulator of G-protein signaling 4
chr19_+_49023283 0.333 NM_181845
 ZNF283
zinc finger protein 283
chr17_+_15543771 0.330 ZNF286A
zinc finger protein 286A
chr5_-_111120817 0.327 NM_004772
 C5orf13
chromosome 5 open reading frame 13
chr5_-_139992621 0.322 NM_000591
 CD14
CD14 molecule
chr17_+_5264195 0.321 RPAIN
RPA interacting protein
chr18_-_45241014 0.321 NM_017653
 DYM
dymeclin
chr22_+_37407921 0.311 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr22_+_37407906 0.309 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr3_+_197951121 0.308 NM_002577
 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr15_+_89444185 0.308 NM_001167580
 SV2B
synaptic vesicle glycoprotein 2B
chr15_+_89444433 0.305 NM_014848
 SV2B
synaptic vesicle glycoprotein 2B
chr12_+_119224506 0.302 NM_012240
 SIRT4
sirtuin 4
chr3_+_199161446 0.299 NM_000996
 RPL35A
ribosomal protein L35a
chr18_+_54958095 0.299 NM_033280
 SEC11C
SEC11 homolog C (S. cerevisiae)
chr10_+_86174665 0.298 FAM190B
family with sequence similarity 190, member B
chr10_+_93548162 0.298 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr19_+_62638474 0.290 NM_001023561
 ZNF749
zinc finger protein 749
chr15_-_72540484 0.287 UBL7
ubiquitin-like 7 (bone marrow stromal cell-derived)
chr9_-_133945064 0.285 NM_004269
 CRSP8P
MED27
mediator complex subunit 27 pseudogene
mediator complex subunit 27
chr2_+_43854681 0.284 NM_001193464
NM_015522
NM_016008
 DYNC2LI1


dynein, cytoplasmic 2, light intermediate chain 1


chr14_-_81069865 0.281 SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr5_-_102926349 0.280 NM_031438
 NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr10_+_93548048 0.276 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr19_+_42553895 0.275 NM_032453
 ZNF527
zinc finger protein 527
chr5_+_140733664 0.271 NM_018919
NM_032086
 PCDHGA6

protocadherin gamma subfamily A, 6

chr19_+_49147219 0.270 NM_013359
 ZNF221
zinc finger protein 221
chr11_+_36572615 0.267 NM_138787
 C11orf74
chromosome 11 open reading frame 74
chr12_-_47250069 0.253 NM_002289
 LALBA
lactalbumin, alpha-
chr3_-_132228273 0.252 NM_014065
 ASTE1
asteroid homolog 1 (Drosophila)
chr19_+_62703113 0.252 NM_198542
 ZNF773
zinc finger protein 773
chr17_+_7457988 0.251 SHBG
sex hormone-binding globulin
chr10_-_62163083 0.250 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr17_-_5263594 0.250 NUP88
nucleoporin 88kDa
chr4_-_153820535 0.245 NM_152680
 TMEM154
transmembrane protein 154
chr19_-_42777486 0.245 NM_016536
 ZNF571
zinc finger protein 571
chr19_+_49408523 0.244 NM_182490
 ZNF227
zinc finger protein 227
chr12_-_102413875 0.242 NM_198521
NM_001099336
 C12orf42

chromosome 12 open reading frame 42

chr2_+_218843358 0.240 NM_001077399
NM_015488
 PNKD

paroxysmal nonkinesigenic dyskinesia

chr19_+_62950001 0.239 ZNF776
zinc finger protein 776
chr2_+_149895274 0.237 NM_194317
 LYPD6
LY6/PLAUR domain containing 6
chr5_-_139993469 0.228 NM_001040021
NM_001174104
NM_001174105
 CD14


CD14 molecule


chr3_+_140545528 0.227 NM_020191
 MRPS22
mitochondrial ribosomal protein S22
chr4_-_89299034 0.226 NM_004827
 ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr1_+_161305188 0.222 NM_005613
 RGS4
regulator of G-protein signaling 4
chr15_-_72540543 0.222 NM_032907
NM_201265
 UBL7

ubiquitin-like 7 (bone marrow stromal cell-derived)

chr8_-_66708967 0.221 NM_018120
 ARMC1
armadillo repeat containing 1
chr1_+_218988199 0.219 NM_017898
 MOSC2
MOCO sulphurase C-terminal domain containing 2
chr22_+_37407925 0.218 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr1_-_109420091 0.218 NM_005645
 TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr11_+_65024889 0.216 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr19_+_63053031 0.215 NM_032828
 ZNF587
zinc finger protein 587
chr9_+_129226473 0.212 NM_007135
 ZNF79
zinc finger protein 79
chr11_+_2877486 0.211 NM_183233
 SLC22A18
solute carrier family 22, member 18
chr19_-_56303434 0.211 NM_145232
 CTU1
cytosolic thiouridylase subunit 1 homolog (S. pombe)
chr10_+_93548119 0.211 NM_025235
 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr9_-_112139908 0.206 NM_001003936
 TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr9_+_129226535 0.206 ZNF79
zinc finger protein 79
chr19_+_49221333 0.205 NM_001129996
NM_013360
 ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222

chr10_-_7493418 0.204 NM_001029880
 SFMBT2
Scm-like with four mbt domains 2
chr14_-_90780604 0.199 NM_001177676
 GPR68
G protein-coupled receptor 68
chr5_+_85949518 0.197 NM_001867
 COX7C
cytochrome c oxidase subunit VIIc
chr14_-_81069951 0.196 NM_005065
 SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr1_+_38250995 0.196 UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr8_-_66708948 0.195 ARMC1
armadillo repeat containing 1
chr8_-_66708954 0.195 ARMC1
armadillo repeat containing 1
chr19_-_44573468 0.190 NM_019088
 PAF1
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr1_-_145608965 0.190 NM_016361
 ACP6
acid phosphatase 6, lysophosphatidic
chr5_+_178219519 0.189 NM_058230
 ZNF354B
zinc finger protein 354B
chr3_+_123779122 0.188 NM_001113523
 PARP15
poly (ADP-ribose) polymerase family, member 15
chr18_+_41938295 0.187 NM_138443
 HAUS1
HAUS augmin-like complex, subunit 1
chr1_+_38250953 0.185 NM_016037
 UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr1_-_33275051 0.184 AK2
adenylate kinase 2
chr19_+_62703136 0.182 ZNF773
zinc finger protein 773
chr1_-_33275015 0.179 AK2
adenylate kinase 2
chr3_-_185218311 0.178 NM_001023587
NM_005688
 ABCC5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

chr19_-_44573343 0.177 PAF1
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr2_-_182229977 0.177 NM_001030311
NM_001030312
NM_001030313
NM_001160277
NM_201548
 CERKL




ceramide kinase-like




chr7_-_107883929 0.176 NM_001193582
NM_001193583
NM_001193584
NM_005010
 NRCAM



neuronal cell adhesion molecule



chrX_-_139694248 0.170 NM_004065
 CDR1
cerebellar degeneration-related protein 1, 34kDa
chr6_+_84626113 0.170 CYB5R4
cytochrome b5 reductase 4
chr10_-_38305458 0.168 NM_145011
 ZNF25
zinc finger protein 25
chr8_+_110415725 0.166 NM_001193557
NM_020189
 ENY2

enhancer of yellow 2 homolog (Drosophila)

chr14_-_76958984 0.161 NM_138791
NM_001113475
 C14orf148

chromosome 14 open reading frame 148

chr3_+_181802592 0.158 NM_001042601
NM_133462
 TTC14

tetratricopeptide repeat domain 14

chr12_+_132167512 0.157 ZNF140
zinc finger protein 140
chr12_+_21175394 0.157 NM_006446
 SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr22_+_37407899 0.152 NM_020243
 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr19_-_41711009 0.151 NM_001012756
NM_001166036
NM_001166037
NM_001166038
 ZNF260



zinc finger protein 260



chr14_-_44500871 0.150 NM_017658
 KLHL28
kelch-like 28 (Drosophila)
chr11_+_85690900 0.150 NM_016401
 C11orf73
chromosome 11 open reading frame 73
chr17_+_15543615 0.149 NM_001130842
NM_020652
 ZNF286A

zinc finger protein 286A

chr19_+_62949972 0.149 NM_173632
 ZNF776
zinc finger protein 776
chr10_-_131799051 0.147 LOC387723
hypothetical LOC387723

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.29 2.99e-10 GO:0006355 regulation of transcription, DNA-dependent
2.21 2.28e-09 GO:0051252 regulation of RNA metabolic process
2.14 3.87e-09 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.11 6.07e-09 GO:0010556 regulation of macromolecule biosynthetic process
2.07 1.18e-08 GO:0010468 regulation of gene expression
1.99 1.16e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.83 1.90e-07 GO:0060255 regulation of macromolecule metabolic process
1.96 2.06e-07 GO:0009889 regulation of biosynthetic process
1.95 2.27e-07 GO:0051171 regulation of nitrogen compound metabolic process
1.96 2.80e-07 GO:0031326 regulation of cellular biosynthetic process
1.67 9.55e-06 GO:0019222 regulation of metabolic process
1.68 3.33e-05 GO:0031323 regulation of cellular metabolic process
1.69 3.38e-05 GO:0080090 regulation of primary metabolic process
1.32 2.00e-03 GO:0065007 biological regulation
1.32 1.10e-02 GO:0050794 regulation of cellular process
1.29 3.37e-02 GO:0050789 regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.40 9.68e-10 GO:0043231 intracellular membrane-bounded organelle
1.35 1.09e-09 GO:0043229 intracellular organelle
1.39 1.10e-09 GO:0043227 membrane-bounded organelle
1.35 1.37e-09 GO:0043226 organelle
1.60 3.22e-09 GO:0005634 nucleus
1.24 6.38e-07 GO:0044424 intracellular part
1.22 8.85e-06 GO:0005622 intracellular
1.09 2.72e-03 GO:0044464 cell part
1.09 2.75e-03 GO:0005623 cell

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.40 2.50e-12 GO:0008270 zinc ion binding
2.25 7.78e-12 GO:0046914 transition metal ion binding
2.11 2.96e-09 GO:0003677 DNA binding
1.74 1.87e-08 GO:0046872 metal ion binding
1.72 3.86e-08 GO:0043169 cation binding
1.72 4.51e-08 GO:0043167 ion binding
1.71 5.00e-06 GO:0003676 nucleic acid binding